Pediatria
O-1 Dosing for two: placental transfer and fetal darunavir exposure
Scritto da Archives of Disease in Childhood current issue   
PediatriaBackground

Fetal drug exposure during pregnancy can be a determinant of fetal drug toxicity or efficacy. Fetal exposure is usually derived from the cord-to-maternal (ctm) concentration ratio. This static parameter does not provide i ... ...

 
O-2 Population and developmental pharmacokinetic analysis to evaluate and optimise cefotaxime dosing regimen in neonates and young infants
Scritto da Archives of Disease in Childhood current issue   
PediatriaBackground

Cefotaxime is one of the most frequently prescribed antibiotics for the treatment of Gram-negative bacterial sepsis in neonates. However, the dosing regi-mens routinely used in clinical practice vary considerably. The obj ... ...

 
O-3 Population pharmacokinetics and dosing optimisation of ceftriaxone in burn infants and children
Scritto da Archives of Disease in Childhood current issue   
PediatriaBackground

Ceftriaxone, a broad spectrum cephalosporin, used as first-line empirical antimicrobial therapy in burn children. Burn injury had shown significant impact on pharmacokinetics of antimicrobials. As paediatric data are limi ... ...

 
O-4 Analysis of voriconazole monitoring data in children with onco-haematological diseases
Scritto da Archives of Disease in Childhood current issue   
PediatriaBackground

Voriconazole (VCZ) is a triazole antifungal agent widely used in immunocompromised patients with suspected or proved invasive fungal infection. The achievement of therapeutic range (1–5 mg/L) is clinically important ... ...

 
O-5 Amikacin disposition and dosing recommendations in neonates with perinatal asphyxia treated with therapeutic hypothermia (amicool study)
Scritto da Archives of Disease in Childhood current issue   
PediatriaBackground

Aminoglycosides are administered to treat (suspected) neonatal sepsis. The pharmacokinetics (PK) of this antibiotic class are expected to be different in neonates with perinatal asphyxia (PA) treated with therapeutic hypo ... ...

 
O-6 Hyperfiltration in the paediatric intensive care unit (hypic) a pilot study
Scritto da Archives of Disease in Childhood current issue   
PediatriaBackground

Hyperfiltration refers to the enhanced re-nal elimination of circulating solute. It is an increasingly recognised phenomenon in critically ill adults, leading to subtherapeutic treatment of renally cleared drugs. Although ... ...

 
O-7 Vasopressin and terlipressin for refractory shock in neonates and children: systematic review meta-analysis and trial sequential analysis
Scritto da Archives of Disease in Childhood current issue   
PediatriaBackground

Vasopressin (AVP) and terlipressin (TP) have been used as last line therapy in refractory shock in children. However, the efficacy and safety of AVP and TP were not determined these populations. We aimed to assess the eff ... ...

 
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